In your body, GLP-1s are powerful hormones made by your gut that send signals to your brain and other key parts of your metabolic system to influence your blood sugar response and insulin, and regulate your appetite and digestion so you can feel full longer and maximize nutrient absorption. Semaglutide (marketed under brand names Wegovy®, Ozempic® and Rybelsus®), along with all other GLP-1s, addresses systems core to metabolic health and helps lower your set point, or the weight your body fights to stay at.